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Cyclopentolate: Wikis


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Systematic (IUPAC) name
2-(dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate
CAS number 512-15-2
ATC code S01FA04
PubChem 2905
Chemical data
Formula C 17H25NO3  
Mol. mass 291.385 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Topic
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Cyclopentolate is a mydriatic and cycloplegic agent commonly used during pediatric eye examinations. Cyclopentolate is also administered as an atropine substitute to reverse muscarinic and CNS effects of indirect cholinomimetic (anti-AChase) administration.

When used in eye drops in pediatric eye examinations, Cyclopentolate 0.5% and 1.0% is used to stop the eye focusing at near distance, enabling the optometrist or ophthalmologist to obtain a more accurate reading of the focusing power of the eyes.

The drops take around 30 minutes to work and around 24 hours to wear off (with patients advised not to drive a vehicle or operate machinery for the first 12 hours). The pupils become wider when Cyclopentolate is administered, making the eyes more sensitive to light. Close objects (and possibly distant objects) will also appear blurred.

Side effects to Cyclopentolate are rare, but can include effects such as disorientation, incoherent speech or visual disturbances during the 24-hour period that the drug has an effect.




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