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Cyclorphan: Wikis


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Systematic (IUPAC) name
CAS number 4163-15-9
ATC code  ?
PubChem 5359966
Chemical data
Formula C 20H27NO 
Mol. mass 297.434 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Cyclorphan is a hallucinogenic opioid mixed agonist-antagonist related to levorphanol discovered in the late 1960s. It is not marketed as an analgesic because of side effects related to its impact on the kappa opioid receptor,[1][2] but has found some use as a research chemical on and off since its discovery.


  1. ^ Herling S, Hein DW, Nemeth MA, Valentino RJ, Woods JH. Discriminative stimulus, antagonist, and rate-decreasing effects of cyclorphan: multiple modes of action. Life Sciences. 1982 Jan 25;30(4):331-41. PMID 6122153
  2. ^ Bertalmio AJ, Woods JH. Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone. Psychopharmacology (Berlin). 1992;106(2):189-94. PMID 1347952


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