The Full Wiki

More info on Cycloserine

Cycloserine: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Cycloserine
Systematic (IUPAC) name
(R)-4-amino-1,2-oxazolidin-3-one
Identifiers
CAS number 68-41-7
ATC code J04AB01
PubChem 6234
DrugBank APRD00894
ChemSpider 5998
Chemical data
Formula C 3H6N2O2  
Mol. mass 102.092 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ~70% to 90%
Metabolism Hepatic
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Cycloserine is an antibiotic effective against Mycobacterium tuberculosis. For the treatment of tuberculosis, it is classified as a second line drug, i.e. its use is only considered if one or more first line drugs cannot be used.

Although in principle active against other bacteria as well, cycloserine is not commonly used in the treatment of infections other than tuberculosis.

Mode of action

The terminal two amino acid residues of the murein precursor lipid II consist of D-alanine, which is produced by the enzyme alanine racemase; the two residues are joined by D-alanine ligase. Both enzymes are competitively inhibited by cycloserine.[1]

Applications and side effects unrelated to antibiotic activity

It is also being trialed for treatment of phobias[2] as well as an adjuvant to conventional treatments for depression, obsessive-compulsive disorder and schizophrenia. It has been experimentally used for treatment of Gaucher's disease.

Recent research suggests that D-cycloserine may be effective in treating chronic pain.[3]

The side effects are mainly central nervous system (CNS) manifestations, i.e. headache, irritability, depression, psychosis convulsions. Co-administration of pyridoxine can reduce the incidence of some of the CNS side effects (e.g. convulsions).

These psychotropic responses are related to D-cycloserine's action as a partial agonist of the neuronal NMDA receptor for glutamate and have been examined in implications with sensory-related fear extinction in the amygdala.[2]

References

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message