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DAA-1097: Wikis

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DAA-1097
Systematic (IUPAC) name
N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide
Identifiers
CAS number 220551-79-1
ATC code  ?
PubChem 9844410
Chemical data
Formula C 24H24ClNO3  
Mol. mass 409.904 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

DAA-1097 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at central benzodiazepine receptors. It has anxiolytic effects in animal studies.[1][2][3]

References

  1. ^ Okuyama S, Chaki S, Yoshikawa R, Ogawa S, Suzuki Y, Okubo T, Nakazato A, Nagamine M, Tomisawa K (1999). "Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106". Life Sciences 64 (16): 1455–64. PMID 10321725.  
  2. ^ Okubo T, Yoshikawa R, Chaki S, Okuyama S, Nakazato A (January 2004). "Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands". Bioorganic & Medicinal Chemistry 12 (2): 423–38. PMID 14723961.  
  3. ^ James ML, Selleri S, Kassiou M (2006). "Development of ligands for the peripheral benzodiazepine receptor". Current Medicinal Chemistry 13 (17): 1991–2001. PMID 16842193.  
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