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DARC (gene): Wikis


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Duffy blood group, chemokine receptor
Symbols DARC; CCBP1; CD234; Dfy; FY; GPD
External IDs OMIM110700 MGI1097689 HomoloGene48067 IUPHAR: FY GeneCards: DARC Gene
Species Human Mouse
Entrez 2532 13349
Ensembl n/a ENSMUSG00000037872
UniProt n/a Q53ZP8
RefSeq (mRNA) NM_002036 NM_010045
RefSeq (protein) NP_002027 NP_034175
Location (UCSC) n/a Chr 1:
175.17 - 175.17 Mb
PubMed search [1] [2]

Duffy blood group, chemokine receptor (DARC), also known as CD234 (Cluster of Differentiation 234), is a human gene.[1]


See also


Further reading

  • Pogo AO, Chaudhuri A (1996). "Duffy and receptors for P. vivax and chemotactic peptides.". Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2 (4): 269–76. PMID 8542025.  
  • Pruenster M, Rot A (2007). "Throwing light on DARC.". Biochem. Soc. Trans. 34 (Pt 6): 1005–8. doi:10.1042/BST0341005. PMID 17073738.  
  • Raeymaekers P, Van Broeckhoven C, Backhovens H, et al. (1988). "The Duffy blood group is linked to the alpha-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1.". Hum. Genet. 78 (1): 76–8. doi:10.1007/BF00291239. PMID 2892777.  
  • Lu ZH, Wang ZX, Horuk R, et al. (1995). "The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain.". J. Biol. Chem. 270 (44): 26239–45. doi:10.1074/jbc.270.44.26239. PMID 7592830.  
  • Tournamille C, Colin Y, Cartron JP, Le Van Kim C (1995). "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.". Nat. Genet. 10 (2): 224–8. doi:10.1038/ng0695-224. PMID 7663520.  
  • Horuk R, Chitnis CE, Darbonne WC, et al. (1993). "A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor.". Science 261 (5125): 1182–4. doi:10.1126/science.7689250. PMID 7689250.  
  • Tournamille C, Le Van Kim C, Gane P, et al. (1995). "Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism.". Hum. Genet. 95 (4): 407–10. doi:10.1007/BF00208965. PMID 7705836.  
  • Iwamoto S, Omi T, Kajii E, Ikemoto S (1995). "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue.". Blood 85 (3): 622–6. PMID 7833467.  
  • Chaudhuri A, Polyakova J, Zbrzezna V, et al. (1993). "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10793–7. doi:10.1073/pnas.90.22.10793. PMID 8248172.  
  • Horuk R, Martin AW, Wang Z, et al. (1997). "Expression of chemokine receptors by subsets of neurons in the central nervous system.". J. Immunol. 158 (6): 2882–90. PMID 9058825.  
  • Tournamille C, Le Van Kim C, Gane P, et al. (1997). "Close association of the first and fourth extracellular domains of the Duffy antigen/receptor for chemokines by a disulfide bond is required for ligand binding.". J. Biol. Chem. 272 (26): 16274–80. doi:10.1074/jbc.272.26.16274. PMID 9195930.  
  • Tournamille C, Le Van Kim C, Gane P, et al. (1998). "Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.". Blood 92 (6): 2147–56. PMID 9731074.  
  • Parasol N, Reid M, Rios M, et al. (1998). "A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.". Blood 92 (7): 2237–43. PMID 9746760.  
  • Olsson ML, Smythe JS, Hansson C, et al. (1999). "The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.". Br. J. Haematol. 103 (4): 1184–91. doi:10.1046/j.1365-2141.1998.01083.x. PMID 9886340.  
  • Lachgar A, Jaureguiberry G, Le Buenac H, et al. (1999). "Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC).". Biomed. Pharmacother. 52 (10): 436–9. doi:10.1016/S0753-3322(99)80021-3. PMID 9921412.  
  • Zimmerman PA, Woolley I, Masinde GL, et al. (2000). "Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13973–7. doi:10.1073/pnas.96.24.13973. PMID 10570183.  
  • Woolley IJ, Kalayjian R, Valdez H, et al. (2002). "HIV nephropathy and the Duffy antigen/receptor for Chemokines in African Americans.". J. Nephrol. 14 (5): 384–7. PMID 11730271.  
  • Hamblin MT, Thompson EE, Di Rienzo A (2002). "Complex signatures of natural selection at the Duffy blood group locus.". Am. J. Hum. Genet. 70 (2): 369–83. doi:10.1086/338628. PMID 11753822.  
  • Patterson AM, Siddall H, Chamberlain G, et al. (2002). "Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium.". J. Pathol. 197 (1): 108–16. doi:10.1002/path.1100. PMID 12081195.  

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