The Full Wiki

More info on DD-transpeptidase

DD-transpeptidase: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

A transpeptidase (EC 3.4.16.4) is a bacterial enzyme that cross-links the peptidoglycan chains to form rigid cell walls. This enzyme is also known by several other names including DD-peptidase, DD-transpeptidase, D-alanyl-D-alanine carboxypeptidase and serine-type D-Ala-D-Ala carboxypeptidase.[1]

The protein transpeptidase is also known as Novel penicillin-binding protein, which is necessary for cell wall peptidoglycan formation, and is inhibited by penicillin.

The antibiotic penicillin irreversibly binds to and inhibits the activity of the transpeptidase enzyme by forming a highly stable penicilloyl-enzyme intermediate. Because of the interaction between penicillin and transpeptidase, this enzyme is also known as "penicillin-binding protein."

References

  1. ^ "E.C.3.4.16.4 Serine-type D-Ala-D-Ala carboxypeptidase". Enzyme Structures Database. http://www.biochem.ucl.ac.uk/bsm/enzymes/ec3/ec04/ec16/ec0004/index.html. Retrieved February 26, 2006.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message