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For the older type of computer memory, see DDR SDRAM.

Discoidin domain receptor family, member 1
Symbols DDR1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
External IDs OMIM600408 MGI99216 HomoloGene68212 GeneCards: DDR1 Gene
RNA expression pattern
PBB GE DDR1 1007 s at tn.png
PBB GE DDR1 207169 x at tn.png
PBB GE DDR1 208779 x at tn.png
More reference expression data
Species Human Mouse
Entrez 780 12305
Ensembl ENSG00000137332 ENSMUSG00000003534
UniProt Q08345 O35407
RefSeq (mRNA) NM_001954 NM_007584
RefSeq (protein) NP_001945 NP_031610
Location (UCSC) Chr c6_COX:
30.99 - 31.01 Mb
Chr 17:
35.29 - 35.31 Mb
PubMed search [1] [2]

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.[1]

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.[1]


Further reading

  • Edelhoff S, Sweetser DA, Disteche CM (1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C.". Genomics 25 (1): 309–11. doi:10.1016/0888-7543(95)80144-B. PMID 7774938.  
  • Shelling AN, Butler R, Jones T, et al. (1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16.". Genomics 25 (2): 584–7. doi:10.1016/0888-7543(95)80065-T. PMID 7789998.  
  • Weiner TM, Liu ET, Craven RJ, Cance WG (1995). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.". Ann. Surg. Oncol. 1 (1): 18–27. doi:10.1007/BF02303537. PMID 7834423.  
  • Laval S, Butler R, Shelling AN, et al. (1995). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.". Cell Growth Differ. 5 (11): 1173–83. PMID 7848919.  
  • Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.". Mol. Cell. Biol. 14 (4): 2713–21. PMID 8139570.  
  • Di Marco E, Cutuli N, Guerra L, et al. (1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.". J. Biol. Chem. 268 (32): 24290–5. PMID 8226977.  
  • Perez JL, Shen X, Finkernagel S, et al. (1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.". Oncogene 9 (1): 211–9. PMID 8302582.  
  • Johnson JD, Edman JC, Rutter WJ (1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–81. doi:10.1073/pnas.90.12.5677. PMID 8390675.  
  • Perez JL, Jing SQ, Wong TW (1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.". Oncogene 12 (7): 1469–77. PMID 8622863.  
  • Valent A, Meddeb M, Danglot G, et al. (1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21.". Hum. Genet. 98 (1): 12–5. doi:10.1007/s004390050152. PMID 8682498.  
  • Playford MP, Butler RJ, Wang XC, et al. (1996). "The genomic structure of discoidin receptor tyrosine kinase.". Genome Res. 6 (7): 620–7. doi:10.1101/gr.6.7.620. PMID 8796349.  
  • Sakuma S, Saya H, Tada M, et al. (1997). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.". FEBS Lett. 398 (2-3): 165–9. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099.  
  • Nemoto T, Ohashi K, Akashi T, et al. (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer.". Pathobiology 65 (4): 195–203. doi:10.1159/000164123. PMID 9396043.  
  • Tanaka K, Nagayama Y, Nakano T, et al. (1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid.". Endocrinology 139 (3): 852–8. doi:10.1210/en.139.3.852. PMID 9492013.  
  • Vogel W, Gish GD, Alves F, Pawson T (1998). "The discoidin domain receptor tyrosine kinases are activated by collagen.". Mol. Cell 1 (1): 13–23. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899.  
  • Shrivastava A, Radziejewski C, Campbell E, et al. (1998). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.". Mol. Cell 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900.  
  • Vogel W, Brakebusch C, Fässler R, et al. (2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin.". J. Biol. Chem. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566.  
  • Foehr ED, Tatavos A, Tanabe E, et al. (2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.". FASEB J. 14 (7): 973–81. PMID 10783152.  
  • Weiner HL, Huang H, Zagzag D, et al. (2001). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors.". Neurosurgery 47 (6): 1400–9. doi:10.1097/00006123-200012000-00028. PMID 11126911.  
  • Mohan RR, Mohan RR, Wilson SE (2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea.". Exp. Eye Res. 72 (1): 87–92. doi:10.1006/exer.2000.0932. PMID 11133186.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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