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Dehydroepiandrosterone sulfate
DHEA sulfate.png
IUPAC name
Other names Prasterone sulfate
Identifiers
Abbreviations DHEAS
CAS number 651-48-9
PubChem 12594
SMILES
Properties
Molecular formula C19H28O5S
Molar mass 368.49 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.

In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1.[1] This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size.

See also

References

  1. ^ Rainey WE, Nakamura Y (February 2008). "Regulation of the adrenal androgen biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3-5): 281–6. doi:10.1016/j.jsbmb.2007.09.015. PMID 17945481.  
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DHEA sulfate
File:DHEA
IUPAC name
Other names Prasterone sulfate
Identifiers
Abbreviations DHEAS
CAS number [651-48-9]
PubChem 12594
SMILES
Properties
Molecular formula C19H28O5S
Molar mass 368.49 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox references

Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.

DHEA sulfate levels decline as a person ages.

References


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