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desert hedgehog homolog (Drosophila)
Symbol DHH
Alt. symbols HHG-3, MGC35145
Entrez 50846
HUGO 2865
OMIM 605423
RefSeq NM_021044
UniProt O43323
Other data
Locus Chr. 12 q13.1

Desert hedgehog homolog (Drosophila), also known as DHH is a human gene.[1][2] The protein encoded by this gene is involved in cell signaling. It is named for the Desert Hedgehog.


This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.[3]


  1. ^ Kamisago M, Kimura M, Furutani Y, Furutani M, Takao A, Momma K, Matsuoka R (1999). "Assignment of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization". Cytogenet. Cell Genet. 87 (1-2): 117–8. doi:10.1159/000015376. PMID 10640830.  
  2. ^ Tate G, Satoh H, Endo Y, Mitsuya T (2000). "Assignment of desert hedgehog (DHH) to human chromosome bands 12q12→q13.1 by in situ hybridization". Cytogenet. Cell Genet. 88 (1-2): 93–4. doi:10.1159/000015495. PMID 10773676.  
  3. ^ "Entrez Gene: desert hedgehog homolog (Drosophila)".  

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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