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DNA damage-inducible transcript 3: Wikis

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DNA-damage-inducible transcript 3
Identifiers
Symbols DDIT3; CEBPZ; CHOP; CHOP10; GADD153; MGC4154
External IDs OMIM126337 MGI109247 HomoloGene3012 GeneCards: DDIT3 Gene
RNA expression pattern
PBB GE DDIT3 209383 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1649 13198
Ensembl ENSG00000175197 ENSMUSG00000025408
UniProt P35638 Q3V405
RefSeq (mRNA) NM_004083 NM_007837
RefSeq (protein) NP_004074 NP_031863
Location (UCSC) Chr 12:
56.2 - 56.2 Mb
Chr 10:
126.69 - 126.7 Mb
PubMed search [1] [2]

DNA damage-inducible transcript 3 is a protein that in humans is encoded by the DDIT3 gene.[1][2]

Contents

Interactions

DNA damage-inducible transcript 3 has been shown to interact with Casein kinase 2, alpha 1,[3] JunD,[4] RPS3A,[5] ATF3,[6] CEBPB,[7][8] C-jun[4] and C-Fos.[4]

References

  1. ^ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol 11 (2): 1009–16. PMID 1990262.  
  2. ^ "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649.  
  3. ^ Ubeda, Mariano; Habener Joel F (Oct. 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. (United States) 278 (42): 40514–20. doi:10.1074/jbc.M306404200. ISSN 0021-9258. PMID 12876286.  
  4. ^ a b c Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMID 10523647.  
  5. ^ Cui, K; Coutts M, Stahl J, Sytkowski A J (Mar. 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. (UNITED STATES) 275 (11): 7591–6. ISSN 0021-9258. PMID 10713066.  
  6. ^ Chen, B P; Wolfgang C D, Hai T (Mar. 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMID 8622660.  
  7. ^ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. (Netherlands) 541 (1-3): 33–9. ISSN 0014-5793. PMID 12706815.  
  8. ^ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. (UNITED STATES) 271 (24): 14285–9. ISSN 0021-9258. PMID 8662954.  

Further reading

  • Ramji DP, Foka P (2002). "CCAAT/enhancer-binding proteins: structure, function and regulation.". Biochem. J. 365 (Pt 3): 561–75. doi:10.1042/BJ20020508. PMID 12006103.  
  • Oyadomari S, Mori M (2004). "Roles of CHOP/GADD153 in endoplasmic reticulum stress.". Cell Death Differ. 11 (4): 381–9. doi:10.1038/sj.cdd.4401373. PMID 14685163.  
  • Aman P, Ron D, Mandahl N, et al. (1993). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).". Genes Chromosomes Cancer 5 (4): 278–85. PMID 1283316.  
  • Park JS, Luethy JD, Wang MG, et al. (1992). "Isolation, characterization and chromosomal localization of the human GADD153 gene.". Gene 116 (2): 259–67. PMID 1339368.  
  • Ron D, Habener JF (1992). "CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.". Genes Dev. 6 (3): 439–53. PMID 1547942.  
  • Eneroth M, Mandahl N, Heim S, et al. (1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.". Cancer Genet. Cytogenet. 48 (1): 101–7. PMID 2372777.  
  • Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.". Nat. Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.  
  • Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.". Nature 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.  
  • Chen BP, Wolfgang CD, Hai T (1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.". Mol. Cell. Biol. 16 (3): 1157–68. PMID 8622660.  
  • Panagopoulos I, Höglund M, Mertens F, et al. (1996). "Fusion of the EWS and CHOP genes in myxoid liposarcoma.". Oncogene 12 (3): 489–94. PMID 8637704.  
  • Wang XZ, Ron D (1996). "Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.". Science 272 (5266): 1347–9. PMID 8650547.  
  • Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ (1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress.". J. Biol. Chem. 271 (24): 14285–9. PMID 8662954.  
  • Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589–99. PMID 10523647.  
  • Cui K, Coutts M, Stahl J, Sytkowski AJ (2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis.". J. Biol. Chem. 275 (11): 7591–6. PMID 10713066.  
  • Gotoh T, Oyadomari S, Mori K, Mori M (2002). "Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP.". J. Biol. Chem. 277 (14): 12343–50. doi:10.1074/jbc.M107988200. PMID 11805088.  
  • Satoh T, Toyoda M, Hoshino H, et al. (2002). "Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells.". Oncogene 21 (14): 2171–80. doi:10.1038/sj.onc.1205279. PMID 11948400.  
  • Qiao D, Im E, Qi W, Martinez JD (2002). "Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis.". Biochim. Biophys. Acta 1583 (1): 108–16. PMID 12069855.  
  • Talukder AH, Wang RA, Kumar R (2002). "Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells.". Oncogene 21 (27): 4289–300. doi:10.1038/sj.onc.1205529. PMID 12082616.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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