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Aspartyl aminopeptidase
External IDs MGI1278328 HomoloGene6110 GeneCards: DNPEP Gene
EC number 3.4.11.-
RNA expression pattern
PBB GE DNPEP 38703 at tn.png
PBB GE DNPEP 201937 s at tn.png
PBB GE DNPEP 217604 at tn.png
More reference expression data
Species Human Mouse
Entrez 23549 13437
Ensembl ENSG00000123992 ENSMUSG00000026209
UniProt Q9ULA0 Q3TVK3
RefSeq (mRNA) NM_012100 NM_016878
RefSeq (protein) NP_036232 NP_058574
Location (UCSC) Chr 2:
219.95 - 219.96 Mb
Chr 1:
75.19 - 75.2 Mb
PubMed search [1] [2]

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.[1][2]

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins.[2]


  1. ^ Wilk S, Wilk E, Magnusson RP (Aug 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". J Biol Chem 273 (26): 15961-70. PMID 9632644.  
  2. ^ a b "Entrez Gene: DNPEP aspartyl aminopeptidase".  

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Prieto I, Hermoso F, Gasparo M, et al. (2004). "Angiotensinase activities in the kidney of renovascular hypertensive rats.". Peptides 24 (5): 755–60. doi:10.1016/S0196-9781(03)00121-9. PMID 12895663.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Wilk S, Wilk E, Magnusson RP (2002). "Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.". Arch. Biochem. Biophys. 407 (2): 176–83. doi:10.1016/S0003-9861(02)00494-0. PMID 12413488.  


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