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2,5-Dimethoxy-4-trifluoromethylamphetamine
Systematic (IUPAC) name
1-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine
Identifiers
CAS number  ?
ATC code  ?
PubChem 10400521
ChemSpider 8575959
Chemical data
Formula C12H16F3NO2
Mol. mass 263.26 g/mol
SMILES eMolecules & PubChem
Synonyms 2,5-dimethoxy-4-trifluoromethylamphetamine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes  ?

2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5HT2A and 5HT2C receptors. In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1] Anecdotal reports from human users suggest that DOTFM is a potent psychedelic with an extremely long duration of action, similar to Br-DFLY.

See also

References

  1. ^ a b Nichols DE, Frescas S, Marona-Lewicka D, et al. (December 1994). "1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist". Journal of Medicinal Chemistry 37 (25): 4346–51. PMID 7996545.  
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DOTFM
Systematic (IUPAC) name
1-(4-(trifluoromethyl)-2,5-dimethoxyphenyl)-2-aminopropane
Identifiers
CAS number  ?
ATC code  ?
PubChem 10400521
Chemical data
Formula C12H16F3NO2 
Mol. mass 263.255 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

DOTFM is an analogue of the phenethylamine derived hallucinogen DOB where the bromine atom has been replaced by a trifluoromethyl group. It was discovered in 1994 by a team at Purdue University.

DOTFM is the amphetamine homolog of the phenethylamine hallucinogen 2C-TFM and is around twice as potent as 2C-TFM in animal studies. It acts as a potent agonist for the 5HT2A and 5HT2C receptors. In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1] Anecdotal reports from human users suggest that DOTFM is a potent hallucinogen with an extremely long duration of action, similar to Br-DFLY.

References

  1. Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. Journal of Medicinal Chemistry. 1994 Dec 9;37(25):4346-51. PMID 7996545

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