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Desmocollin 3
Symbols DSC3; DSC1; DSC2; CDHF3; DSC; DSC4; HT-CP
External IDs OMIM600271 MGI1194993 HomoloGene1462 GeneCards: DSC3 Gene
RNA expression pattern
PBB GE DSC3 206032 at tn.png
PBB GE DSC3 206033 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1825 13507
Ensembl ENSG00000134762 ENSMUSG00000059898
UniProt Q14574 P55850
RefSeq (mRNA) NM_001941 NM_007882
RefSeq (protein) NP_001932 NP_031908
Location (UCSC) Chr 18:
26.83 - 26.88 Mb
Chr 18:
20.11 - 20.15 Mb
PubMed search [1] [2]

Desmocollin-3 is a protein that in humans is encoded by the DSC3 gene.[1][2][3]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[3]


DSC3 has been shown to interact with PKP3.[4]


  1. ^ Amagai M, Wang Y, Minoshima S, Kawamura K, Green KJ, Nishikawa T, Shimizu N (Jul 1995). "Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12". Genomics 25 (1): 330–2. PMID 7774948.  
  2. ^ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol 121 (3): 481–3. PMID 8486729.  
  3. ^ a b "Entrez Gene: DSC3 desmocollin 3".  
  4. ^ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMID 12707304.  

Further reading

  • Arnemann J, Spurr NK, Wheeler GN, et al. (1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).". Genomics 10 (3): 640–5. doi:10.1016/0888-7543(91)90446-L. PMID 1889810.  
  • King IA, Sullivan KH, Bennett R, Buxton RS (1995). "The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms.". J. Invest. Dermatol. 105 (3): 314–21. doi:10.1111/1523-1747.ep12319935. PMID 7665906.  
  • Kawamura K, Watanabe K, Suzuki T, et al. (1994). "cDNA cloning and expression of a novel human desmocollin.". J. Biol. Chem. 269 (42): 26295–302. PMID 7929347.  
  • Buxton RS, Wheeler GN, Pidsley SC, et al. (1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18.". Genomics 21 (3): 510–6. doi:10.1006/geno.1994.1309. PMID 7959727.  
  • Nuber UA, Schäfer S, Stehr S, et al. (1997). "Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.". Eur. J. Cell Biol. 71 (1): 1–13. PMID 8884173.  
  • Kurzen H, Moll I, Moll R, et al. (1998). "Compositionally different desmosomes in the various compartments of the human hair follicle.". Differentiation 63 (5): 295–304. doi:10.1046/j.1432-0436.1998.6350295.x. PMID 9810708.  
  • Moll I, Houdek P, Schäfer S, et al. (1999). "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model.". Arch. Dermatol. Res. 291 (7-8): 437–46. doi:10.1007/s004030050435. PMID 10482015.  
  • Hanakawa Y, Amagai M, Shirakata Y, et al. (2000). "Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes.". J. Cell. Sci. 113 ( Pt 10): 1803–11. PMID 10769211.  
  • Whittock NV, Hunt DM, Rickman L, et al. (2000). "Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.". Biochem. Biophys. Res. Commun. 276 (2): 454–60. doi:10.1006/bbrc.2000.3500. PMID 11027496.  
  • Gadhavi PL, Greenwood MD, Strom M, et al. (2001). "The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction.". Biochem. Biophys. Res. Commun. 281 (2): 520–8. doi:10.1006/bbrc.2001.4375. PMID 11181078.  
  • Klus GT, Rokaeus N, Bittner ML, et al. (2001). "Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer.". Int. J. Oncol. 19 (1): 169–74. PMID 11408939.  
  • Weiske J, Schöneberg T, Schröder W, et al. (2001). "The fate of desmosomal proteins in apoptotic cells.". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.  
  • Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.". J. Cell. Sci. 116 (Pt 7): 1219–33. doi:10.1242/jcs.00275. PMID 12615965.  
  • Bonné S, Gilbert B, Hatzfeld M, et al. (2003). "Defining desmosomal plakophilin-3 interactions.". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMID 12707304.  
  • Oshiro MM, Watts GS, Wozniak RJ, et al. (2003). "Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.". Oncogene 22 (23): 3624–34. doi:10.1038/sj.onc.1206545. PMID 12789271.  
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.  
  • Oshiro MM, Kim CJ, Wozniak RJ, et al. (2006). "Epigenetic silencing of DSC3 is a common event in human breast cancer.". Breast Cancer Res. 7 (5): R669–80. doi:10.1186/bcr1273. PMID 16168112.  


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