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Deltex homolog 2 (Drosophila)
Symbols DTX2; KIAA1528; MGC71098; RNF58
External IDs MGI1921448 HomoloGene56904 GeneCards: DTX2 Gene
RNA expression pattern
PBB GE DTX2 215732 s at tn.png
More reference expression data
Species Human Mouse
Entrez 113878 74198
Ensembl ENSG00000091073 ENSMUSG00000004947
UniProt Q86UW9 Q8R3P2
RefSeq (mRNA) XM_001133140 NM_023742
RefSeq (protein) XP_001133140 NP_076231
Location (UCSC) Chr 7:
75.93 - 75.97 Mb
Chr 5:
136.28 - 136.32 Mb
PubMed search [1] [2]

Protein deltex-2 is a protein that in humans is encoded by the DTX2 gene.[1]


Further reading

  • Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.". Development 121 (8): 2633–44. PMID 7671825.  
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.  
  • Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.  
  • Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takeyama K, Aguiar RC, Gu L, et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMID 16400609.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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