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Updated live from Wikipedia, last check: May 31, 2012 21:26 UTC (55 seconds ago)

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DU145 (DU-145) and PC3 human prostate cancer cell lines are the "classical" cell lines of prostatic cancer[1]. DU145 cells have moderate metastatic potential compared to PC3 cells which have high metastatic potential[2].

The DU145 cell line was derived from brain metastasis. DU145 are not hormone sensitive and don’t express PSA (Prostate Specific Antigen).

References

  1. ^ Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D (April 2006). "DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation". FEBS Lett. 580 (9): 2294–300. doi:10.1016/j.febslet.2006.03.041. PMID 16580667.  
  2. ^ Pulukuri SM, Gondi CS, Lakka SS, et al (October 2005). "RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo". J. Biol. Chem. 280 (43): 36529–40. doi:10.1074/jbc.M503111200. PMID 16127174. PMC 1351057. http://www.jbc.org/cgi/content/full/280/43/36529.  
  • Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF (March 1978). "Isolation of a human prostate carcinoma cell line (DU 145)". Int. J. Cancer 21 (3): 274–81. doi:10.1002/ijc.2910210305. PMID 631930.  







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