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Dacemazine: Wikis


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Systematic (IUPAC) name
CAS number 518-61-6
ATC code none
PubChem 68846
Chemical data
Formula C 16H16N2OS 
Mol. mass 284.376 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Dacemazine (INN, also known as Ahistan and Histantine)[1] is a phenothiazine derivative which acts as an histamine antagonist at the H1 subtype. First described in 1951, it was never marketed as a drug on its own, although a combination of dacemazine and di-tert-butylnaphthalenesulfonate was sold as an antispasmodic and antitussive under the trade name Codopectyl.[1] It was also assessed as a possible anticancer drug.[2]


  1. ^ a b David J. Triggle; C. R. Ganellin, F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. pp. p. 711. ISBN 0-412-46630-9.,M1.   Retrieved on August 2, 2008 through Google Book Search.
  2. ^ Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C. The anticarcinogenic effect of dimethylaminoacetyl-phentiazide (ahistan). Kiserletes Orvostudomany. 1952 Aug;4(4):260-2. PMID 13023855


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