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Dacetuzumab: Wikis


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Dacetuzumab ?
Monoclonal antibody
Type whole antibody
Source humanized (from mouse)
Target CD40
CAS number 880486-59-9
ATC code none
Chemical data
Formula C6452H9964N1732O1998S42 
Mol. mass 145.1 kDa (for the peptide)
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Dacetuzumab (also known as SGN-40 or huS2C6) is a humanized monoclonal antibody[1] being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma[2] and hematological malignancies.[3]

This drug was developed by Seattle Genetics, Inc.


  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Dacetuzumab, American Medical Association.
  2. ^ Advani, R.; Forero-torres, A.; Furman, R. R.; Rosenblatt, J. D.; Younes, A.; Ren, H.; Harrop, K.; Whiting, N. et al. (2009). "Phase I Study of the Humanized Anti-CD40 Monoclonal Antibody Dacetuzumab in Refractory or Recurrent Non-Hodgkin's Lymphoma". Journal of Clinical Oncology 27 (26): 4371. doi:10.1200/JCO.2008.21.3017. PMID 19636010.  edit
  3. ^ Khubchandani; Czuczman, MS; Hernandez-Ilizaliturri, FJ (2009). "Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies". Current opinion in investigational drugs (London, England : 2000) 10 (6): 579–87. PMID 19513947.  edit


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