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Dalbavancin
Systematic (IUPAC) name
 ?
Identifiers
CAS number 171500-79-1
ATC code J01XA04
PubChem 16134410
Chemical data
Formula C 88H100Cl2N10O28  
Mol. mass 1755.634 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Intravenous

Dalbavancin (INN, trade name Zeven) is a novel second-generation lipoglycopeptide antibiotic. It belongs to the same class as vancomycin, the most widely-used and one of the few treatments available to patients infected with methicillin-resistant Staphylococcus aureus (MRSA).[1]

It possesses in vitro activity against a variety of Gram-positive pathogens[2][3] including MRSA and MRSE.[4] It is a once-weekly, two-dose antibiotic that Pfizer acquired when it bought Vicuron Pharmaceuticals in 2005.[5]

On September 9, 2008, Pfizer announced that it will withdraw all marketing applications in order to conduct another Phase 3 clinical trial.[6]

References and notes

  1. ^ Vicuron Pharmaceuticals Submits New Drug Application for Dalbavancin to U.S. Food and Drug Administration
  2. ^ Chen AY, Zervos MJ, Vazquez JA (2007). "Dalbavancin: a novel antimicrobial". Int. J. Clin. Pract. 61 (5): 853–63. doi:10.1111/j.1742-1241.2007.01318.x. PMID 17362476.  
  3. ^ Das B, Sarkar C, Biswas R, Pandey S (2008). "Review: dalbavancin-a novel lipoglycopeptide antimicrobial for gram positive pathogens". Pak J Pharm Sci 21 (1): 78–88. PMID 18166524.  
  4. ^ Dalbavancin: A Novel Lipoglycopeptide Antibacterial
  5. ^ UPDATE 1-Pfizer says US FDA wants more data on antibiotic
  6. ^ Pfizer Inc. (2008-09-09). "Pfizer Will Withdraw Global Marketing Applications for Dalbavancin to Conduct a New Trial". Press release. http://www.businesswire.com/news/pfizer/20080909005943/en. Retrieved 2008-09-11.  







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