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CD55 molecule, decay accelerating factor for complement (Cromer blood group)

PDB rendering based on 1h03.
Available structures
1h03, 1h04, 1h2p, 1h2q, 1m11, 1nwv, 1ojv, 1ojw, 1ojy, 1ok1, 1ok2, 1ok3, 1ok9, 1uot, 1upn, 2c8i
Identifiers
Symbols CD55; CR; DAF; TC
External IDs OMIM125240 MGI104850 HomoloGene479 GeneCards: CD55 Gene
RNA expression pattern
PBB GE CD55 201925 s at tn.png
PBB GE CD55 201926 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1604 13136
Ensembl ENSG00000196352 ENSMUSG00000026399
UniProt P08174 Q3TU32
RefSeq (mRNA) NM_000574 NM_010016
RefSeq (protein) NP_000565 NP_034146
Location (UCSC) Chr 1:
205.56 - 205.6 Mb
Chr 1:
132.27 - 132.29 Mb
PubMed search [1] [2]

Complement decay-accelerating factor also known as CD55 is a protein that in humans is encoded by the CD55 gene.[1]

Decay accelerating factor is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Contents

Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; this, coupled with CD59 absence leads to PNH.

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Infectious diseases

DAF is used as a receptor by some coxsackieviruses and other enteroviruses.[2] Recombinant soluble DAF-Fc has been tested in mice as an anti-enterovirus therapy for heart damage;[3] however, the human enterovirus which was tested binds much more strongly to human DAF than to mouse or rat DAF. Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF.[4] and DAF-Fc has yet to be tested in humans.

See also

References

  1. ^ Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML (April 1987). "Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 2007–11. PMID 2436222. 
  2. ^ Karnauchow TM, Tolson DL, Harrison BA, Altman E, Lublin DM, Dimock K (August 1996). "The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55)". J. Virol. 70 (8): 5143–52. PMID 8764022. 
  3. ^ Yanagawa B, Spiller OB, Choy J, Luo H, Cheung P, Zhang HM, Goodfellow IG, Evans DJ, Suarez A, Yang D, McManus BM (January 2003). "Coxsackievirus B3-associated myocardial pathology and viral load reduced by recombinant soluble human decay-accelerating factor in mice". Lab. Invest. 83 (1): 75–85. PMID 12533688. 
  4. ^ Spiller OB, Goodfellow IG, Evans DJ, Almond JW, Morgan BP (January 2000). "Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF". J. Infect. Dis. 181 (1): 340–3. doi:10.1086/315210. PMID 10608785. 

Further reading

  • Selinka HC, Wolde A, Sauter M, et al. (2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.". Med. Microbiol. Immunol. 193 (2-3): 127–31. doi:10.1007/s00430-003-0193-y. PMID 12920584. 
  • Mikesch JH, Schier K, Roetger A, et al. (2007). "The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy.". Cell. Oncol. 28 (5-6): 223–32. PMID 17167176. 

External links


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