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Decitabine: Wikis

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Decitabine
Systematic (IUPAC) name
4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-
1,3,5-triazin-2(1H)-one
Identifiers
CAS number 2353-33-5
ATC code L01BC08
PubChem 451668
ChemSpider 397844
Chemical data
Formula C 8H12N4O4  
Mol. mass 228.0859 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding <1%
Metabolism  ?
Half life 30 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat. D
Legal status
Routes Intravenous
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Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, is a cytosine analog.

Contents

Mechanism

It is a hypomethylating agent.[1][2] It hypomethylates DNA by inhibiting DNA methyltransferase.

It functions in the same way as azacitidine.

Clinical uses

Decitabine is indicated for the treatment of myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and Intermediate-1, Intermediate-2, and High-Risk International Prognostic Scoring System groups.

Further reading

  • Moon C, Kim SH (June 2009). "Use of epigenetic modification to induce FOXP3 expression in naïve T cells". Transplant Proc. 41 (5): 1848-54. PMID 19545742.  

References

External links

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