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Demecolcine: Wikis

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Demecolcine
Systematic (IUPAC) name
(S)-1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5 H-benzo[a]heptalen-9-one
Identifiers
CAS number 477-30-5
ATC code L01CC01
PubChem 2832
Chemical data
Formula C 21H25NO5  
Mol. mass 371.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Demecolcine is a drug used in chemotherapy.

During cell division Demecolcine inhibits mitosis at metaphase by inhibiting spindle formation.

Medically Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle (1).

In animal cloning procedures Demecolcine makes an ovum eject its nucleus, creating space for insertion of a new nucleus (2).

1. Brit med J., 1965, 1, 495 – 496.

2. Reprod Nutr Dev. 2006 Mar-Apr;46(2):219-26.

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