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Denaverine: Wikis


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Systematic (IUPAC) name
2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS number 3579-62-2
3321-06-0 (hydrochloride)
ATCvet code QG02CX90
PubChem CID 71130
Chemical data
Formula C24H33NO3 
Mol. mass 383.52 g/mol
Pharmacokinetic data
Bioavailability 8% (suppositories),
37% (oral solution)
Metabolism mainly hepatic, at least 11 metabolites
Half-life 34 hours
Therapeutic considerations
Pregnancy cat. Gr 1 (Germany)
Legal status Prescription only
Routes intramuscular injection, suppositories

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]


  1. ^ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
  2. ^ (in German) Rote Liste (2005 ed.). Frankfurt. ISBN 3-87193-306-6. 
  3. ^ Dinnendahl, V, Fricke, U, ed (2010) (in German). Arzneistoff-Profile. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-98-46-3. 


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