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Dexfenfluramine: Wikis


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Systematic (IUPAC) name
CAS number 3239-44-9
ATC code A08AA04
PubChem 66265
DrugBank APRD00648
ChemSpider 59646
Chemical data
Formula C 12H16F3N 
Mol. mass 231.257 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding 36%
Metabolism  ?
Half life 17-20 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV (US) Withdrawn from market
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. After it was removed in the US, dexfenfluramine was also pulled out in other global markets. It was later superseded by sibutramine, which is a safer alternative to both dexfenfluramine and fenfluramine.

The drug was manufactured by Interneuron Pharmaceuticals and marketed by Wyeth-Ayerst Laboratories. It is the enantiomer of levofenfluramine.

See also


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