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Dexketoprofen: Wikis


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Systematic (IUPAC) name
(2S)-2-[3-(benzoyl)phenyl]propanoic acid
ATC code M01AE17
PubChem 667550
Chemical data
Formula C16H14O3 
Mol. mass 254.28056 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM (UK)

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug.



Short-term treatment of mild to moderate pain, including dysmenorrhoea.

How does it work

Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.


  1. This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
  2. For fast relief of pain, take at least 30 minutes before food, as food delays the absorption of this medicine from the gut.
  3. This medicine is not for long term use

Use with caution in

  1. Decreased heart function
  2. Disorders involving the formation of blood cells (haematopoietic disorders)
  3. Elderly people
  4. Excess retention of water in the body tissues (fluid retention)
  5. History of allergies
  6. Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
  7. Low volume of circulating blood (hypovolaemia)
  8. Mild to moderately decreased liver function
  9. Mildly decreased kidney function
  10. Syndrome with symptoms of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon (mixed connective tissue disease)

Not to be used in

  1. Active bleeding
  2. Allergy to aspirin or other medicines in this class
  3. Asthma or history of asthma
  4. Bleeding disorders
  5. Bleeding from the stomach or intestines
  6. Breastfeeding
  7. Children
  8. Crohn's disease
  9. History of stomach or duodenal ulcers or indigestion
  10. Inflammation of the bowel and back passage
  11. Inherited tendency to bleed (haemorrhagic diathesis)
  12. Moderate to severely decreased kidney function
  13. Peptic ulcers
  14. Pregnancy
  15. Severe heart failure
  16. Severely decreased liver function

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  1. The manufacturer states not to use this medicine during pregnancy and breastfeeding as there is insufficient safety information available. Seek medical advice from your doctor.

Label warnings

  1. Take this medication half to one hour before food.


Adult: 12.5mg every 4-6 hours, or 25mg every 8 hours; max 75mg daily. Elderly: initially max 50mg daily. Child: not recommended.



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