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Systematic (IUPAC) name
carboxylic acid
CAS number 13739-02-1
ATC code M01AX21
PubChem 26248
Chemical data
Formula C 19H12O8  
Mol. mass 368.294 g/mol
Synonyms Diacetylrhein, diacerhein
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism Hepatic: deacetylation to rhein, later glucuronidation and sulfate conjugation
Half life 4 to 5 hours
Excretion Renal (30%)
Therapeutic considerations
Pregnancy cat. Lacking information
Legal status
Routes Oral

Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.

A 2005 Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in diacerein has a small effect in improving pain and slowing the progress of osteoarthritis (in the hip). .[1]

Side effects

The most common side effects of diacerein treatment are gastrointestinal, such as diarrhea.[1][2]


  1. ^ a b Fidelix TS, Soares BG, Trevisani VF (2006). "Diacerein for osteoarthritis". Cochrane database of systematic reviews (Online) (1): CD005117. doi:10.1002/14651858.CD005117.pub2. PMID 16437519.   Free summary
  2. ^ (French) "Diacereine". BIAM. 1999-03-24. Retrieved 2007-06-13.  


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