The Full Wiki

More info on Diacerein

Diacerein: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Diacerein
Systematic (IUPAC) name
4,5-diacetyloxy-9,10-dioxo-anthracene-2-
carboxylic acid
Identifiers
CAS number 13739-02-1
ATC code M01AX21
PubChem 26248
Chemical data
Formula C 19H12O8  
Mol. mass 368.294 g/mol
Synonyms Diacetylrhein, diacerhein
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism Hepatic: deacetylation to rhein, later glucuronidation and sulfate conjugation
Half life 4 to 5 hours
Excretion Renal (30%)
Therapeutic considerations
Pregnancy cat. Lacking information
Legal status
Routes Oral

Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.

A 2005 Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in diacerein has a small effect in improving pain and slowing the progress of osteoarthritis (in the hip). .[1]

Side effects

The most common side effects of diacerein treatment are gastrointestinal, such as diarrhea.[1][2]

References

  1. ^ a b Fidelix TS, Soares BG, Trevisani VF (2006). "Diacerein for osteoarthritis". Cochrane database of systematic reviews (Online) (1): CD005117. doi:10.1002/14651858.CD005117.pub2. PMID 16437519.   Free summary
  2. ^ (French) "Diacereine". BIAM. 1999-03-24. http://www.biam2.org/www/Sub5020.html. Retrieved 2007-06-13.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message