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Dicycloverine
Systematic (IUPAC) name
2-(diethylamino)ethyl bi(cyclohexane)-1-carboxylate
Identifiers
CAS number 77-19-0
ATC code A03AA07
PubChem 3042
DrugBank APRD00113
ChemSpider 2934
Chemical data
Formula C 19H35NO2  
Mol. mass 309.487 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding >99%
Metabolism  ?
Half life 5 h
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Dicyclomine, also known as dicycloverine, is an anticholinergic that blocks muscarinic receptors. Dicyclomine is known as dicycloverine hydrochloride in the UK. Dicycloverine has 72 per cent of the anti-muscarinic power of atropine. It was invented in the United States in 1947.

Contents

Clinical uses

Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.

In America, it is sold under the trade names: Bentyl, Byclomine, Dibent, Di-Spaz, Dilomine.

It is present in antibacterial burn cream (trade name Ambix) in combination with phenol.

In the UK it is sold under the trade names: Merbentyl (containing 10mg dicycloverine) and Merbentyl 20 (containing 20mg dicycloverine).

It is also sold in the UK as part of a multi-ingredient preparation under the trade name Kolanticon (Peckforton Pharmaceuticals), which in addition to dicycloverine, contains an antiflatulent (simethicone) and two antacids (aluminium hydroxide and magnesium oxide).

It is sold under the trade names Bentylol (Hoechst Marion Roussel), Formulex (ICN), and Lomine (Riva) in Canada. it is sold under the trade names spasmo proxivon and spasmo plus in India

Side effects

Dicyclomines can cause a range of anticholinergic side effects such as dry mouth, nausea and at higher doses, deliriant effects. Abuse of this drug has been reported in Brazil and Egypt.[1] Brief euphoria and an aphrodisiac effect are also known to occur in some cases,

References

  1. ^ Carlini EA. Preliminary note: dangerous use of anticholinergic drugs in Brazil. Drug and Alcohol Dependence. 1993 Mar;32(1):1-7.
  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

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