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Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number 134-80-5
ATC code A08AA03
PubChem 7029
DrugBank 7029
ChemSpider 6762
Chemical data
Formula C13H19NO
Mol. mass 205.30 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. B
Legal status Schedule IV (US)
Routes Oral

Diethylcathinone (Tenuate, Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil), also known as diethylpropion or amfepramone, is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.

Contents

Pharmacology

Diethylcathinone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone.[1] Ethcathinone (and therefore diethylcathinone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively.[1] As a result, ethcathinone and diethylcathinone can essentially be considered selective norepinephrine releasing agents (NRAs).

Neurotoxicity

Diethylcathinone has been found to be neurotoxic in that it causes long-term depletions of serotonin similarly to methamphetamine and MDMA ("Ecstasy").[2]

Legality

Diethylcathinone is classified as a Schedule IV controlled substance in the United States.

See also

References

  1. ^ a b Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry 6 (17): 1845–59. PMID 17017961. http://www.bentham-direct.org/pages/content.php?CTMC/2006/00000006/00000017/0004R.SGM.  
  2. ^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301







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