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Diethylthiambutene: Wikis


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Diethylthiambutene
Systematic (IUPAC) name
N,N-diethyl-4,4-dithiophen-2-yl-but-3-en-2-amine
Identifiers
CAS number 86-14-6
ATC code none
PubChem 149833
Chemical data
Formula C 16H21NS2  
Mol. mass 291.477 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 152–153 °C (306–307 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule I (US)
Routes  ?

Diethylthiambutene (Thiambutene, Themalon, Diethibutin, N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine) is an opioid analgesic drug developed in the 1950s[1] which was mainly used as an anesthetic in veterinary medicine and continues, along with the other two thiambutenes Dimethylthiambutene and Ethylmethylthiambutene to be used for this purpose, particularly in Japan.[2][3] It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.

References

  1. ^ BECKETT AH, CASY AF, HARPER NJ, PHILLIPS PM. Analgesics and their antagonists: some steric and chemical considerations. II. The influence of the basic group on physico-chemical properties and the activity of methadone and thiambutene-type compounds. Journal of Pharmacy and Pharmacology. 1956 Nov;8(11):860-73.
  2. ^ Hayes MJ. The use of thiambutene hydrochloride. The Veterinary Record. 1968 Nov 16;83(20):528.
  3. ^ Harbison WD, Slocombe RF, Watts SJ, Stewart GA. Thiambutene and acepromazine as analgesic and preanaesthetic agents in horses and sheep. Australian Veterinary Journal. 1974 Dec;50(12):543-6.







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