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Diethyltryptamine: Wikis


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Systematic (IUPAC) name
CAS number 7558-72-7
ATC code none
PubChem 6090
Chemical data
Formula C 14H20N2  
Mol. mass 216.32 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 169–171 °C (336–340 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Class A (UK) Schedule I (US)
Routes  ?

DET, also known under its chemical name N,N-diethyltryptamine and as T-9 [1 ], is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100 mg without the aid of MAO inhibitors lasting about 2-4 hours.



DET is an analogue the common tryptamine hallucinogen N,N-Dimethyltryptamine or DMT. DET is sometimes preferred over DMT because it can be taken orally whereas DMT cannot. This is because the enzyme monoamine oxidase degrades DMT into an inactive compound before it is absorbed. To overcome this, it must be administered in a different manner, i.e. intravenously, intramuscularly, by inhalation, by insufflation, or rectally. Because DET has ethyl groups attached to its nitrogen atom monoamine oxidase is unable to degrade it. This is true for many other tryptamines with larger nitrogen substitutents.


The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.[2]


Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.[3]

Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties. [4] Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.[5] With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

See also


External links

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