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Dihydrexidine: Wikis

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Dihydrexidine
Systematic (IUPAC) name
5,6,6a,7,8,12b-hexahydro-benzo(a)phenanthridine-10,11-diol
Identifiers
CAS number 137417-08-4
ATC code none
PubChem 5311070
Chemical data
Formula C17H17NO2 
Mol. mass 267.322 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Dihydrexidine (LS-186,899) is a selective full agonist at the dopamine D1 and D5 receptors. It has approximately 10-fold selectivity for D1 and D5 over the D2 receptor. Dihydrexidine was investigated for the treatment of Parkinson's disease and schizophrenia but in an early clinical trial the drug was given intravenously and led to profound hypotension so development was halted. This drug continues to be studied, however, and is now in clinical trials to assess its efficacy in improving the cognitive and working memory deficits in schizophrenia.[1]

References

  1. ^ Zhang J, Xiong B, Zhen X, Zhang A. (2009). "Dopamine D1 receptor ligands: where are we now and where are we going.". Med Res Rev. 29 (2): 272–294. PMID 18642350. 
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