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Dihydroergotamine: Wikis

  

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Dihydroergotamine
Systematic (IUPAC) name
(2R,4R,7R)-N-[(1 S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.0 2,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.02,7.0 12,16]hexadeca-1(16),9,12,14-tetraene-4-carboxamide
Identifiers
CAS number 511-12-6
ATC code N02CA01
PubChem 10531
DrugBank APRD00476
Chemical data
Formula C 33H37N5O5  
Mol. mass 583.678 g/mol
Synonyms (5'α)-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 9 hours
Excretion Bile
Therapeutic considerations
Pregnancy cat. X(US)
Legal status -only (US)
Routes  ?

Dihydroergotamine (brand names D.H.E. 45 and Migranal) is an ergot alkaloid used to treat migraines.

It is believed to act upon serotonin receptors.[1]

References

  1. ^ Schaerlinger B, Hickel P, Etienne N, Guesnier L, Maroteaux L (September 2003). "Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy". British journal of pharmacology 140 (2): 277–84. doi:10.1038/sj.bjp.0705437. PMID 12970106. PMC 1574033. http://dx.doi.org/10.1038/sj.bjp.0705437.  

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