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Dimemorfan
Systematic (IUPAC) name
(9α,13α,14α)-3,17-dimethylmorphinan
Identifiers
CAS number 36309-01-0
ATC code R05DA11
PubChem 3037918
Chemical data
Formula C 18H25N 
Mol. mass 255.398 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.[1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.[3]

See also

References

  1. ^ Hui-Hung Wang, Jyh-Wei Chien, Yueh-Ching Chou, Jyh-Fei Liao and Chieh-Fu Chen. Anti-amnesic effect of dimemorfan in mice. British Journal of Pharmacology (2003) 138, 941–949.
  2. ^ Eun-Joo Shin, Seung-Yeol Nah, Won-Ki Kim, Kwang Ho Ko, Wang-Kee Jhoo, Yong-Kwang Lim, Joo Young Cha, Chieh-Fu Chen and Hyoung-Chun Kim. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. British Journal of Pharmacology (2005) 144, 908–918.
  3. ^ Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (March 1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain Research 821 (2): 516–9. PMID 10064839. http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(99)01125-7.  
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