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Dimethocaine
Systematic (IUPAC) name
(3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate
Identifiers
CAS number 94-15-5
ATC code none
PubChem 7177
Chemical data
Formula C16H26N2O2 
Mol. mass 278.39
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Dimethocaine, also known as larocaine, is a local anesthetic with stimulant properties nearly as potent as cocaine.[1][2][3]

The p-NH2 pharmacophore in dimethocaine is a relatively uncommon structural feature for a dopamine reuptake inhibitor, although it is also present in other compounds such as GYKI-52895.

See also

Percent inhibition of 50 nM [3H]dopamine uptake in striatal synaptosomes at 0.1-100 uM compound concentration

References

  1. ^ Woodward JJ, Compton DM, Balster RL, Martin BR (April 1995). "In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter". Eur. J. Pharmacol. 277 (1): 7–13. doi:10.1016/0014-2999(95)00042-J. PMID 7635175. http://linkinghub.elsevier.com/retrieve/pii/001429999500042J. 
  2. ^ Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. Psychopharmacology (Berlin). 1996 Oct;127(4):323-7. PMID 8923567
  3. ^ Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse. 2005 Dec 15;58(4):220-8. PMID 16206183 PDF







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