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Dinoxyline: Wikis


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From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
ATC code none
PubChem 9819126
Chemical data
Formula C15H13NO3 
Mol. mass 255.268
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Dinoxyline is a synthetic compound developed for scientific research, which acts as a potent full agonist at all five dopamine receptor subtypes.[1][2][3]


  1. ^ Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry 12 (6): 1403–12. doi:10.1016/j.bmc.2004.01.008. PMID 15018913. 
  2. ^ Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular Pharmacology 68 (4): 1039–48. doi:10.1124/mol.105.012153. PMID 15985612. 
  3. ^ Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Medicinal Research Reviews 29 (2): 272–94. doi:10.1002/med.20130. PMID 18642350. 


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