Dissociatives are a class of psychoactive drugs which are said to reduce or block signals to the conscious mind from other parts of the brain.[1] Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances.[2] Some which are nonselective in action and affect the dopamine [3] and/or opioid[4] systems may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.
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These four groups of dissociatives have slightly different effects but also share similarities separating them from other classes of hallucinogens. They are markedly different from psychedelics such as LSD [9] and magic mushrooms [10], where alert and fully conscious users experience cognitive distortion while simultaneously interacting with the "real world". In contrast dissociatives are marked by more internal effects such as closed eye visuals and detachment from the surrounding environment. Nitrous oxide has very different effects however, and even at low doses includes auditory distortions. Unlike with many other psychedelic chemicals, salvia divinorum [11] users are generally not ambulatory and the experience is frequently dissociative. Often a very brief trance is entered, where the user experiences an intense and very realistic dream state. On the other hand, the effect of salvia on emotion has been reported to be less marked than that of true psychedelics.
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