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Systematic (IUPAC) name
mixture of (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate and (1-ethylpiperidin-3-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetate
CAS number 8015-54-1
ATC code  ?
PubChem 111040
Chemical data
Formula C 20H29NO3  
Mol. mass 331.448 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ditran (JB-329) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB).

Ditran is composed of a mixture of 70% 1-ethyl- 2-pyrrolidinylmethyl- alpha- phenylcyclopentylglycolate and 30% 1-ethyl- 3-piperidyl- alpha- phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N- methyl- 3 -piperidyl benzilate, but is less potent than QNB.[1][2]

There has been a modest amount of scientific research using this mixture,[3][4] but most modern research using these kind of anticholinergic drugs uses N- methyl- 3- piperidyl benzilate due to its wider availability.

See also


  1. ^ Siegfried Franke, Peter Franz and Werner Warnke. Lehrbuch der Militärchemie Bd 1, Militärverlag der Deutschen Demokratischen Republik Ost-Berlin, Deutscher Militärverlag, 1974.
  2. ^ Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, Volume 1 (1982). Commission on Life Sciences. The National Academies Press. pp191-195.
  3. ^ Volle RL, Alkadhi KA, Branisteanu DD, Reynolds LS, Epstein PM, Smilowitz H, Lambert JJ, Henderson EG. Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane. Journal of Pharmacology and Experimental Therapeutics. 1982 Jun;221(3):570-6. PMID 6123584
  4. ^ Vanderwolf CH, Stewart DJ. Joint cholinergic-serotonergic control of neocortical and hippocampal electrical activity in relation to behavior: effects of scopolamine, ditran, trifluoperazine and amphetamine. Physiology and Behaviour. 1986;38(1):57-65. PMID 3786502


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