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ADP-ribosyltransferase 4 (Dombrock blood group)
Symbols ART4; CD297; DO; DOK1
External IDs OMIM110600 MGI1202710 HomoloGene10883 GeneCards: ART4 Gene
RNA expression pattern
PBB GE ART4 207220 at tn.png
More reference expression data
Species Human Mouse
Entrez 420 109978
Ensembl ENSG00000111339 ENSMUSG00000030217
UniProt Q93070 n/a
RefSeq (mRNA) NM_021071 NM_026639
RefSeq (protein) NP_066549 NP_080915
Location (UCSC) Chr 12:
14.87 - 14.89 Mb
Chr 6:
136.81 - 136.82 Mb
PubMed search [1] [2]

Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.[1][2] ART4 has also been designated as CD297 (cluster of differentiation 297).

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[2]

Mouse Mutant Alleles for Art4
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Art4
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. Art4tm1aWTSI(KOMP)
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Art4 region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Art4: see Knockout mouse


  1. ^ Koch-Nolte F, Haag F, Braren R, Kuhl M, Hoovers J, Balasubramanian S, Bazan F, Thiele HG (Apr 1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics 39 (3): 370-6. doi:10.1006/geno.1996.4520. PMID 9119374.  
  2. ^ a b "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)".  

Further reading

  • Reid ME (2003). "The Dombrock blood group system: a review.". Transfusion 43 (1): 107–14. doi:10.1046/j.1537-2995.2003.00283.x. PMID 12519438.  
  • Tippett P (1967). "Genetics of the Dombrock blood group system.". J. Med. Genet. 4 (1): 7–11. doi:10.1136/jmg.4.1.7. PMID 6034522.  
  • Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p.". Hum. Genet. 98 (5): 518–21. doi:10.1007/s004390050251. PMID 8882867.  
  • Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2.". Vox Sang. 79 (1): 53–6. doi:10.1046/j.1423-0410.2000.7910053.x. PMID 10971215.  
  • Gubin AN, Njoroge JM, Wojda U, et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.". Blood 96 (7): 2621–7. PMID 11001920.  
  • Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.". Vox Sang. 81 (1): 49–51. doi:10.1046/j.1423-0410.2001.00052.x. PMID 11520417.  
  • Rios M, Hue-Roye K, Øyen R, et al. (2002). "Insights into the Holley- and Joseph- phenotypes.". Transfusion 42 (1): 52–8. doi:10.1046/j.1537-2995.2002.00004.x. PMID 11896313.  
  • Rios M, Storry JR, Hue-Roye K, et al. (2002). "Two new molecular bases for the Dombrock null phenotype.". Br. J. Haematol. 117 (3): 765–7. doi:10.1046/j.1365-2141.2002.03524.x. PMID 12028057.  
  • Glowacki G, Braren R, Firner K, et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.". Protein Sci. 11 (7): 1657–70. doi:10.1110/ps.0200602. PMID 12070318.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements.". Biochim. Biophys. Acta 1730 (3): 173–86. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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