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Dopa decarboxylase inhibitor: Wikis

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A DOPA decarboxylase inhibitor (DDCI) or aromatic L-amino acid decarboxylase inhibitor (AAADI) is a type of drug which inhibits the metabolism of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase (DDC).

Indications

Peripheral DDCIs which are incapable of crossing the protective blood-brain-barrier (BBB) are used in augmentation of L-DOPA (Levodopa) in the treatment of Parkinson's disease (PD) to block the peripheral conversion of L-DOPA into dopamine for the purpose of reducing adverse side effects.[1]

List of DDCIs

  • Benserazide (Madopar, Prolopa, Modopar, Madopark, Neodopasol, EC-Doparyl, etc)
  • Carbidopa (Lodosyn, Sinemet, Parcopa, Atamet, Stalevo, etc)
  • Methyldopa (Aldomet, Aldoril, Dopamet, Dopegyt, etc)

References

  1. ^ "Editorial: Dopa decarboxylase inhibitors". British medical journal 4 (5939): 250–1. November 1974. PMID 4425849.  
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