Dopamine receptor D5: Wikis


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Dopamine receptor D5
Symbols DRD5; DBDR; DRD1B; DRD1L2; MGC10601
External IDs OMIM126453 MGI94927 HomoloGene20216 IUPHAR: D5 GeneCards: DRD5 Gene
RNA expression pattern
PBB GE DRD5 208486 at tn.png
More reference expression data
Species Human Mouse
Entrez 1816 13492
Ensembl ENSG00000169676 ENSMUSG00000039358
UniProt P21918 Q8BLD9
RefSeq (mRNA) NM_000798 NM_013503
RefSeq (protein) NP_000789 NP_038531
Location (UCSC) Chr 4:
9.39 - 9.39 Mb
Chr 5:
38.61 - 38.61 Mb
PubMed search [1] [2]

D(1B) dopamine receptor is a protein that in humans is encoded by the DRD5 gene.[1][2][1]

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase.[3] This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosome 1 and chromosome 2.[2]



The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet, however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available.



No selective ligands known as of yet.


  • 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D1[4]
Chemical structure of a D5-preferring ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol.[4]


Dopamine receptor D5 has been shown to interact with GABRG2.[5]

See also


  1. ^ a b Polymeropoulos MH, Xiao H, Merril CR (Mar 1992). "The human D5 dopamine receptor (DRD5) maps on chromosome 4". Genomics 11 (3): 777–8. PMID 1774076. 
  2. ^ a b "Entrez Gene: DRD5 dopamine receptor D5". 
  3. ^ Sidhu A (1998). "Coupling of D1 and D5 dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling". Mol. Neurobiol. 16 (2): 125–34. doi:10.1007/BF02740640. PMID 9588624. 
  4. ^ a b Mohr P, Decker M, Enzensperger C, Lehmann J (2006). "Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist". J. Med. Chem. 49 (6): 2110–6. doi:10.1021/jm051237e. PMID 16539400. 
  5. ^ Liu, F; Wan Q, Pristupa Z B, Yu X M, Wang Y T, Niznik H B (Jan. 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature (ENGLAND) 403 (6767): 274–80. doi:10.1038/35002014. ISSN 0028-0836. PMID 10659839. 

Further reading

  • Missale C, Nash SR, Robinson SW, et al. (1998). "Dopamine receptors: from structure to function.". Physiol. Rev. 78 (1): 189–225. PMID 9457173. 
  • Grandy DK, Allen LJ, Zhang Y, et al. (1992). "Chromosomal localization of three human D5 dopamine receptor genes.". Genomics 13 (4): 968–73. doi:10.1016/0888-7543(92)90009-H. PMID 1387108. 
  • Eubanks JH, Altherr M, Wagner-McPherson C, et al. (1992). "Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus.". Genomics 12 (3): 510–6. doi:10.1016/0888-7543(92)90442-U. PMID 1532789. 
  • Sunahara RK, Guan HC, O'Dowd BF, et al. (1991). "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.". Nature 350 (6319): 614–9. doi:10.1038/350614a0. PMID 1826762. 
  • Tiberi M, Jarvie KR, Silvia C, et al. (1991). "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491–5. doi:10.1073/pnas.88.17.7491. PMID 1831904. 
  • Grandy DK, Zhang YA, Bouvier C, et al. (1991). "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9175–9. doi:10.1073/pnas.88.20.9175. PMID 1833775. 
  • Weinshank RL, Adham N, Macchi M, et al. (1991). "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.". J. Biol. Chem. 266 (33): 22427–35. PMID 1834671. 
  • Sobell JL, Lind TJ, Sigurdson DC, et al. (1995). "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.". Hum. Mol. Genet. 4 (4): 507–14. doi:10.1093/hmg/4.4.507. PMID 7633397. 
  • Beischlag TV, Marchese A, Meador-Woodruff JH, et al. (1995). "The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.". Biochemistry 34 (17): 5960–70. doi:10.1021/bi00017a025. PMID 7727453. 
  • Sherrington R, Mankoo B, Attwood J, et al. (1994). "Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1.". Genomics 18 (2): 423–5. doi:10.1006/geno.1993.1489. PMID 8288248. 
  • Sidhu A, Kimura K, Uh M, et al. (1998). "Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.". J. Neurochem. 70 (6): 2459–67. PMID 9603210. 
  • Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Liu F, Wan Q, Pristupa ZB, et al. (2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors.". Nature 403 (6767): 274–80. doi:10.1038/35002014. PMID 10659839. 
  • Misbahuddin A, Placzek MR, Chaudhuri KR, et al. (2004). "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.". Neurology 58 (1): 124–6. PMID 11781417. 
  • Kabbani N, Negyessy L, Lin R, et al. (2002). "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor.". J. Neurosci. 22 (19): 8476–86. PMID 12351722. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hemby SE, Trojanowski JQ, Ginsberg SD (2003). "Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.". J. Comp. Neurol. 456 (2): 176–83. doi:10.1002/cne.10525. PMID 12509874. 
  • Zheng S, Yu P, Zeng C, et al. (2003). "Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.". Hypertension 41 (3): 604–10. doi:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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