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Dopamine receptor agonist: Wikis

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From Wikipedia, the free encyclopedia

A dopamine agonist is a compound that activates dopamine receptors in the absence of the dopamine ligand. Dopamine agonists activate signaling pathways through the dopamine receptor and trimeric G-proteins, ultimately leading to changes in gene transcription.

Contents

Uses

Some medical drugs act as dopamine agonists; they are typically used for treating Parkinson's disease and certain pituitary tumors (prolactinoma), and may be useful for restless legs syndrome (RLS). Both Requip (Ropinirole) and Mirapex (Pramipexole) are FDA-approved for the treatment of RLS. There is also an ongoing clinical trial to test the effectiveness of Requip (ropinirole), a dopamine agonist, in reversing the symptoms of SSRI-induced sexual dysfunction and Post-SSRI sexual dysfunction (PSSD).[1]

Side-effects

Some of the common side effects of dopamine agonists include:[2][3]

Examples

Examples of dopamine agonists include:

Some, such as fenoldopam, are selective for dopamine receptor D1.[5]

See also

References

  1. ^ ClinicalTrials.gov NCT00334048 - "Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo"
  2. ^ "MedlinePlus Drug Information: Pramipexole (Systemic)". United States National Library of Medicine. http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203739.html. Retrieved 2006-09-27.  
  3. ^ Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly 66 (1): 87–95. doi:10.1007/BF02238717. http://www.springerlink.com/content/y42v466374524k1m/. Retrieved 2008-09-06.  
  4. ^ FDA Announces Voluntary Withdrawal of Pergolide Products
  5. ^ Ng SS, Pang CC (March 2000). "In vivo venodilator action of fenoldopam, a dopamine D(1)-receptor agonist". Br. J. Pharmacol. 129 (5): 853–8. doi:10.1038/sj.bjp.0703119. PMID 10696081. PMC 1571905. http://dx.doi.org/10.1038/sj.bjp.0703119.  

6. Avanzi M, Uber E, Bonfa F. Pathological gambling in two patients on dopamine replacement therapy for Parkinson’s disease. Neurol Sci 2004; 25:98–101[Medline]

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