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Dorzolamide

Systematic (IUPAC) name
(4S,6S)-2-ethylamino-4-methyl-5,5-dioxo- 5λ6,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
Identifiers
CAS number	130693-82-2 120279-96-1
ATC code	S01EC03
PubChem	3154
DrugBank	APRD00577
Chemical data
Formula	C10H16N2O4S3
Mol. mass	324.443 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Protein binding	~33%
Half life	4 months
Therapeutic considerations
Pregnancy cat.	?
Legal status

Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

The combination of dorzolamide with timolol is marketed under the trade name Cosopt.

References

Further reading

• Kubinyi H (1999). "Chance favors the prepared mind--from serendipity to rational drug design". J Recept Signal Transduct Res 19 (1-4): 15–39. doi:10.3109/10799899909036635. PMID 10071748. 
• Plummer C, MacKay E, Gelatt K (2006). "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.". Vet Ophthalmol 9 (4): 245–9. doi:10.1111/j.1463-5224.2006.00469.x. PMID 16771760. 
• Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.". Am J Ophthalmol 141 (5): 850–8. doi:10.1016/j.ajo.2005.12.030. PMID 16546110. 
• Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness.". Braz J Med Biol Res 39 (2): 277–81. doi:10.1590/S0100-879X2006000200015. PMID 16470316.