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Doxofylline: Wikis


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Systematic (IUPAC) name
CAS number 69975-86-6
ATC code R03DA11
PubChem 50942
Chemical data
Formula C11H14N4O4 
Mol. mass 266.25 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Doxofylline (INN) is a xanthine derivative drug used in the treatment of asthma.[1]

It has antitussive[citation needed] and bronchodilator[2] effects, and acts as a phosphodiesterase inhibitor. [3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly less side effects.[4]


  1. ^ Cirillo R, Barone D, Franzone JS (1988). "Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors". Arch Int Pharmacodyn Ther 295: 221–37. PMID 3245738. 
  2. ^ Poggi R, Brandolese R, Bernasconi M, Manzin E, Rossi A (October 1989). "Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure". Chest 96 (4): 772–8. doi:10.1378/chest.96.4.772. PMID 2791671. 
  3. ^ Dini FL, Cogo R (2001). "Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects". Curr Med Res Opin 16 (4): 258–68. doi:10.1185/030079901750120196. PMID 11268710. 
  4. ^ Sankar J, Lodha R, Kabra SK (March 2008). "Doxofylline: The next generation methylxanthine". Indian J Pediatr 75 (3): 251–4. doi:10.1007/s12098-008-0054-1. PMID 18376093. 


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