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Dyslipidemia: Wikis

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Dyslipidemia
Classification and external resources
ICD-10 E78.
ICD-9 272
MeSH D050171

Dyslipidemia is a disruption in the amount of lipids in the blood. In western societies, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dyslipidaemia.[1]

Classification

There are two major ways in which dyslipidemias are classified:

  • Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
  • Etiology, or the reason for the condition (genetic, or secondary to another condition.) This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well defined genetic conditions that are usually easy to identify.

Fredrickson Classification:[1]

Phenotype I IIa IIb III IV V
Elevated Lipoprotein Chylomicron LDL LDL and VLDL IDL Triglycerides VLDL and chylomicrons

Types

Increases Decreases
Lipid
Lipoprotein
Both

References

  1. ^ Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.
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