The Full Wiki

More info on E-box

E-box: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

An E-box is a DNA sequence which usually lies upstream of a gene in a promoter region. The consensus sequence for the E-box element is CANNTG, with a palindromic canonical sequence of CACGTG.[1] Transcription factors containing the basic-helix-loop-helix protein structural motif typically bind to E-boxes or related variant sequences and enhance transcription of the downstream gene.

Proteins that interact with E-boxes


  1. ^ Chaudhary, Jaideep; Michael K. Skinner. "Basic Helix-Loop-Helix Proteins Can Act at the E-Box within the Serum Response Element of the c-fos Promoter to Influence Hormone-Induced Promoter Activation in Sertoli Cells". Molecular Endocrinology 12 (5): 774–786.  


Got something to say? Make a comment.
Your name
Your email address