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E2F transcription factor 2
Symbols E2F2; E2F-2
External IDs OMIM600426 MGI1096341 HomoloGene48264 GeneCards: E2F2 Gene
Species Human Mouse
Entrez 1870 242705
Ensembl ENSG00000007968 ENSMUSG00000018983
UniProt Q14209 Q3TZQ9
RefSeq (mRNA) NM_004091 NM_177733
RefSeq (protein) NP_004082 NP_808401
Location (UCSC) Chr 1:
23.71 - 23.73 Mb
Chr 4:
135.44 - 135.47 Mb
PubMed search [1] [2]

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]



E2F2 has been shown to interact with BRD2,[4][5] Retinoblastoma protein[6] and RYBP.[7]

See also


  1. ^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (Jan 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol 13 (12): 7802–12. PMID 8246995.  
  2. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Jan 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol 13 (12): 7813–25. PMID 8246996.  
  3. ^ "Entrez Gene: E2F2 E2F transcription factor 2".  
  4. ^ Crowley, Thomas E; Kaine Emily M, Yoshida Manabu, Nandi Anindita, Wolgemuth Debra J (Aug. 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. (United States) 16 (8): 1727–37. ISSN 0888-8809. PMID 12145330.  
  5. ^ Denis, G V; Vaziri C, Guo N, Faller D V (Aug. 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. (UNITED STATES) 11 (8): 417–24. ISSN 1044-9523. PMID 10965846.  
  6. ^ Lee, Changwook; Chang Jeong Ho, Lee Hyun Sook, Cho Yunje (Dec. 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. (United States) 16 (24): 3199–212. doi:10.1101/gad.1046102. ISSN 0890-9369. PMID 12502741.  
  7. ^ Schlisio, Susanne; Halperin Terri, Vidal Miguel, Nevins Joseph R (Nov. 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. (England) 21 (21): 5775–86. ISSN 0261-4189. PMID 12411495.  

Further reading

  • Dyson N (1998). "The regulation of E2F by pRB-family proteins.". Genes Dev. 12 (15): 2245–62. doi:10.1101/gad.12.15.2245. PMID 9694791.  
  • Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins.". Mol. Cell. Biol. 15 (5): 2536–46. PMID 7739537.  
  • Karlseder J, Rotheneder H, Wintersberger E (1996). "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.". Mol. Cell. Biol. 16 (4): 1659–67. PMID 8657141.  
  • Lin SY, Black AR, Kostic D, et al. (1996). "Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction.". Mol. Cell. Biol. 16 (4): 1668–75. PMID 8657142.  
  • Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMID 8755520.  
  • Magae J, Wu CL, Illenye S, et al. (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.". J. Cell. Sci. 109 ( Pt 7): 1717–26. PMID 8832394.  
  • Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.  
  • Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (1997). "The subcellular localization of E2F-4 is cell-cycle dependent.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. doi:10.1073/pnas.94.10.5095. PMID 9144196.  
  • Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (1998). "Differential activities of E2F family members: unique functions in regulating transcription.". Mol. Carcinog. 22 (3): 190–8. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145.  
  • Halaban R, Cheng E, Smicun Y, Germino J (2000). "Deregulated E2F transcriptional activity in autonomously growing melanoma cells.". J. Exp. Med. 191 (6): 1005–16. doi:10.1084/jem.191.6.1005. PMID 10727462.  
  • Takahashi Y, Rayman JB, Dynlacht BD (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.". Genes Dev. 14 (7): 804–16. PMID 10766737.  
  • Denis GV, Vaziri C, Guo N, Faller DV (2001). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.". Cell Growth Differ. 11 (8): 417–24. PMID 10965846.  
  • Wu L, Timmers C, Maiti B, et al. (2001). "The E2F1-3 transcription factors are essential for cellular proliferation.". Nature 414 (6862): 457–62. doi:10.1038/35106593. PMID 11719808.  
  • Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.  
  • Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.  
  • Crowley TE, Kaine EM, Yoshida M, et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID 12145330.  
  • Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". Embo J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMID 12411495.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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