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E4F1: Wikis


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E4F transcription factor 1
Symbols E4F1; E4F; MGC99614
External IDs OMIM603022 MGI109530 HomoloGene3259 GeneCards: E4F1 Gene
RNA expression pattern
PBB GE E4F1 218524 at tn.png
More reference expression data
Species Human Mouse
Entrez 1877 13560
Ensembl ENSG00000167967 ENSMUSG00000024137
UniProt n/a n/a
RefSeq (mRNA) NM_004424 NM_007893
RefSeq (protein) NP_004415 NP_031919
Location (UCSC) Chr 16:
2.21 - 2.23 Mb
Chr 17:
24.17 - 24.18 Mb
PubMed search [1] [2]

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]



E4F1 has been shown to interact with P16,[4] Retinoblastoma protein[5] and P53.[4][6]


  1. ^ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (Nov 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1-2): 99–100. PMID 9763670.  
  2. ^ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (Dec 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–37. PMID 8828041.  
  3. ^ a b "Entrez Gene: E4F1 E4F transcription factor 1".  
  4. ^ a b Rizos, Helen; Diefenbach Eve, Badhwar Prerna, Woodruff Sarah, Becker Therese M, Rooney Robert J, Kefford Richard F (Feb. 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. (United States) 278 (7): 4981–9. doi:10.1074/jbc.M210978200. ISSN 0021-9258. PMID 12446718.  
  5. ^ Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C (Jul. 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7738–43. doi:10.1073/pnas.130198397. ISSN 0027-8424. PMID 10869426.  
  6. ^ Sandy, P; Gostissa M, Fogal V, Cecco L D, Szalay K, Rooney R J, Schneider C, Del Sal G (Jan. 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene (ENGLAND) 19 (2): 188–99. doi:10.1038/sj.onc.1203250. ISSN 0950-9232. PMID 10644996.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.". Mol. Cell. Biol. 17 (4): 1890–903. PMID 9121437.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Rooney RJ, Daniels RR, Jenkins NA, et al. (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.". Mamm. Genome 9 (4): 320–3. doi:10.1007/s003359900758. PMID 9530632.  
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.  
  • Sandy P, Gostissa M, Fogal V, et al. (2000). "p53 is involved in the p120E4F-mediated growth arrest.". Oncogene 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.  
  • Fajas L, Paul C, Zugasti O, et al. (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMID 10869426.  
  • Rizos H, Diefenbach E, Badhwar P, et al. (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fenton SL, Dallol A, Agathanggelou A, et al. (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.". Cancer Res. 64 (1): 102–7. doi:10.1158/0008-5472.CAN-03-2622. PMID 14729613.  
  • Nakamura Y, Igarashi K, Suzuki T, et al. (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.". Am. J. Pathol. 165 (6): 2019–31. PMID 15579445.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Paul C, Lacroix M, Iankova I, et al. (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1.". Oncogene 25 (40): 5475–84. doi:10.1038/sj.onc.1209567. PMID 16652157.  
  • Le Cam L, Linares LK, Paul C, et al. (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.". Cell 127 (4): 775–88. doi:10.1016/j.cell.2006.09.031. PMID 17110336.  
  • Cvetanovic M, Rooney RJ, Garcia JJ, et al. (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.". EMBO Rep. 8 (7): 671–7. doi:10.1038/sj.embor.7400983. PMID 17557114.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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