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EA-3167
Systematic (IUPAC) name
1-azabicyclo[2.2.2]octan-8-yl 2-cyclopentyl-2-hydroxy-2-phenylethanoate
Identifiers
CAS number 26758-53-2
ATC code  ?
PubChem 33597
Chemical data
Formula C 20H29NO3  
Mol. mass 329.433 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

EA-3167 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal incapacitating agents. EA-3167 has identical effects to QNB, but is even more potent and longer lasting, with an effective dose when administered by injection of as little as 2.5μg/kg (i.e. 0.2 milligrams for an 80kg person), and a duration of 120-240 hours (5-10 days).[1][2] However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.

See also

References

  1. ^ Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, Volume 1 (1982). Commission on Life Sciences. The National Academies Press. pp195-196.
  2. ^ Ketchum JS. Chemical Warfare Secrets Almost Forgotton. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc 2006. ISBN 978-1-4243-0080-8
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