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EBV nuclear antigen 3: Wikis

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EBV nuclear antigen 3 is a family of viral proteins associated with Epstein-Barr virus.

  • EBNA-3A
  • EBNA-3B
  • EBNA-3C

These genes also bind the host RBP-Jκ protein.

EBNA-3C can recruit a ubiquitin-ligase and has been shown to target cell cycle regulators like pRb[1][2]

References

  1. ^ Knight JS, Sharma N, Robertson ES (2005). "SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen". Mol. Cell. Biol. 25 (5): 1749–63. doi:10.1128/MCB.25.5.1749-1763.2005. PMID 15713632.  
  2. ^ Knight JS, Sharma N, Robertson ES (2005). "Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18562–6. doi:10.1073/pnas.0503886102. PMID 16352731.  
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