The Full Wiki

More info on EDF1

EDF1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Endothelial differentiation-related factor 1

PDB rendering based on 1x57.
Available structures
1x57
Identifiers
Symbols EDF1; EDF-1; MBF1; MGC9058
External IDs OMIM605107 MGI1891227 HomoloGene2809 GeneCards: EDF1 Gene
RNA expression pattern
PBB GE EDF1 209058 at tn.png
PBB GE EDF1 209059 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8721 59022
Ensembl ENSG00000107223 n/a
UniProt O60869 n/a
RefSeq (mRNA) NM_003792 NM_021519
RefSeq (protein) NP_003783 NP_067494
Location (UCSC) Chr 9:
138.88 - 138.88 Mb
n/a
PubMed search [1] [2]

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[1][2][3]

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[3]

Interactions

EDF1 has been shown to interact with Peroxisome proliferator-activated receptor gamma,[4] TATA binding protein[4][5][6] and Liver X receptor alpha.[4]

References

  1. ^ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (Dec 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem 273 (47): 31119–24. PMID 9813014.  
  2. ^ Ballabio E, Mariotti M, De Benedictis L, Maier JA (Apr 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053.  
  3. ^ a b "Entrez Gene: EDF1 endothelial differentiation-related factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8721.  
  4. ^ a b c Brendel, Carole; Gelman Laurent, Auwerx Johan (Jun. 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. (United States) 16 (6): 1367–77. ISSN 0888-8809. PMID 12040021.  
  5. ^ Mariotti, M; De Benedictis L, Avon E, Maier J A (Aug. 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. (UNITED STATES) 275 (31): 24047–51. doi:10.1074/jbc.M001928200. ISSN 0021-9258. PMID 10816571.  
  6. ^ Kabe, Y; Goto M, Shima D, Imai T, Wada T, Morohashi K i, Shirakawa M, Hirose S, Handa H (Nov. 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. (UNITED STATES) 274 (48): 34196–202. ISSN 0021-9258. PMID 10567391.  

Further reading

  • Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1.". Mol. Cell. Biol. 14 (5): 3013–21. PMID 8164657.  
  • Ozaki J, Takemaru KI, Ikegami T, et al. (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1.". Genes Cells 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174.  
  • Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator.". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.  
  • Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.  
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Bolognese F, Pitarque-Martì M, Lo Cicero V, et al. (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription.". Gene 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message