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Endothelial differentiation-related factor 1

PDB rendering based on 1x57.
Available structures
Symbols EDF1; EDF-1; MBF1; MGC9058
External IDs OMIM605107 MGI1891227 HomoloGene2809 GeneCards: EDF1 Gene
RNA expression pattern
PBB GE EDF1 209058 at tn.png
PBB GE EDF1 209059 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8721 59022
Ensembl ENSG00000107223 n/a
UniProt O60869 n/a
RefSeq (mRNA) NM_003792 NM_021519
RefSeq (protein) NP_003783 NP_067494
Location (UCSC) Chr 9:
138.88 - 138.88 Mb
PubMed search [1] [2]

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[1][2][3]

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[3]


EDF1 has been shown to interact with Peroxisome proliferator-activated receptor gamma,[4] TATA binding protein[4][5][6] and Liver X receptor alpha.[4]


  1. ^ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (Dec 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem 273 (47): 31119–24. PMID 9813014.  
  2. ^ Ballabio E, Mariotti M, De Benedictis L, Maier JA (Apr 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053.  
  3. ^ a b "Entrez Gene: EDF1 endothelial differentiation-related factor 1".  
  4. ^ a b c Brendel, Carole; Gelman Laurent, Auwerx Johan (Jun. 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. (United States) 16 (6): 1367–77. ISSN 0888-8809. PMID 12040021.  
  5. ^ Mariotti, M; De Benedictis L, Avon E, Maier J A (Aug. 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. (UNITED STATES) 275 (31): 24047–51. doi:10.1074/jbc.M001928200. ISSN 0021-9258. PMID 10816571.  
  6. ^ Kabe, Y; Goto M, Shima D, Imai T, Wada T, Morohashi K i, Shirakawa M, Hirose S, Handa H (Nov. 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. (UNITED STATES) 274 (48): 34196–202. ISSN 0021-9258. PMID 10567391.  

Further reading

  • Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1.". Mol. Cell. Biol. 14 (5): 3013–21. PMID 8164657.  
  • Ozaki J, Takemaru KI, Ikegami T, et al. (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1.". Genes Cells 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174.  
  • Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator.". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.  
  • Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.  
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Bolognese F, Pitarque-Martì M, Lo Cicero V, et al. (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription.". Gene 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.  


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