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EGIS-12233: Wikis


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Systematic (IUPAC) name
CAS number  ?
ATC code  ?
PubChem 11525867
Chemical data
Formula C 24H28Cl3N3O 
Mol. mass 480.856 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

EGIS-12233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]


  1. ^ Volk B, Barkóczy J, Hegedus E, Udvari S, Gacsályi I, Mezei T, Pallagi K, Kompagne H, Lévay G, Egyed A, Hársing LG Jr, Spedding M, Simig G. (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists. Journal of Medicinal Chemistry. 2008 Apr 24;51(8):2522-32. PMID 18361484
  2. ^ Doleviczényi Z, Vizi ES, Gacsályi I, Pallagi K, Volk B, Hársing LG Jr, Halmos G, Lendvai B, Zelles T. 5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism. Neurochemical Research. 2008 Nov;33(11):2364-72. PMID 18663573


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