The Full Wiki

More info on EGIS-12233

EGIS-12233: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

EGIS-12233
Systematic (IUPAC) name
5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
Identifiers
CAS number  ?
ATC code  ?
PubChem 11525867
Chemical data
Formula C 24H28Cl3N3O 
Mol. mass 480.856 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

EGIS-12233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]

References

  1. ^ Volk B, Barkóczy J, Hegedus E, Udvari S, Gacsályi I, Mezei T, Pallagi K, Kompagne H, Lévay G, Egyed A, Hársing LG Jr, Spedding M, Simig G. (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists. Journal of Medicinal Chemistry. 2008 Apr 24;51(8):2522-32. PMID 18361484
  2. ^ Doleviczényi Z, Vizi ES, Gacsályi I, Pallagi K, Volk B, Hársing LG Jr, Halmos G, Lendvai B, Zelles T. 5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism. Neurochemical Research. 2008 Nov;33(11):2364-72. PMID 18663573
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message